PHASE II TRIAL OF AKT INHIBITOR MK-2206 IN PATIENTS WITH ADVANCED BREAST CANCER WHO HAVE TUMORS WITH PIK3CA OR AKT MUTATIONS, AND/OR PTEN LOSS/PTEN MUTATION

Abstract Background The PI3K/AKT pathway is activated through PIK3CA or AKT1 mutations and PTEN loss in breast cancer.We conducted a phase II trial with an allosteric AKT inhibitor MK-2206 in patients with advanced GLOST BOND HAIR GLUE breast cancer who had tumors with PIK3CA/AKT1 mutations and/or PTEN loss/mutation.Methods The primary endpoint was

Cardiac tamponade is a rare but serious emergency condition in the pediatric population.As treatment, a pericardial drain is often placed to evacuate the Home fluid.We present a case of a 4-year-old girl with cardiac tamponade secondary to renal failure.After conditioner spray the tamponade resolved, she suffered cardiovascular collapse upon attemp

This paper quantifies the benefits of flattening the curve (with a constant total patient load over the study period) on the risk of a hospital bed shortage in a pandemic.Using discrete-event simulation of patient care paths in hospitals, synthetic data that eliminates issues of confounding affects from the simultaneous occurrence of regional respo

In order to solve the problem of reflection Tanks/Jerseys cracks in semi-rigid base asphalt pavement, a study of temperature-type reflection crack expansion is carried out according to the typical climatic characteristics of Guilin, Guangxi Province.According to the theory of fatigue fracture mechanics, the stress intensity factor analysis at the c